George Church and a team led by him
at the Wyss Institute for Biologically Inspired Engineering and Harvard Medical
School (HMS) achieved storing data in bacteria and tapping. They published this
study on 12 July 2017 in Nature.
Like a computer using binary system,
to save information, DNA uses 4 types of bases; A(Adenine), T(Thymine),
G(Guanine), C(Cytosine). To use bases as binary system, researchers translate base
sequence into binary system; A into 1·0, T into 0·1, C into 0·0, and G into 1·1.
▲ Source : Seth Shipman, Harvard Medical School, Boston “We designed strategies
that essentially translate the digital information contained in each pixel of
an image or frame as well as the frame number into a DNA code, that, with
additional sequences, is incorporated into spacers. Each frame thus becomes a
collection of spacers,” Shipman said. (DNA code is made up 3 of A, T, G, C.
Each base can be used more than 2 times, like AAA or GGA) “We then provided
spacer collections for consecutive frames chronologically to a population of
bacteria which, using Cas1/Cas2 activity, added them to the CRISPR arrays in
their genomes. And after retrieving all arrays again from the bacterial
population by DNA sequencing, we finally were able to reconstruct all frames of
the galloping horse movie and the order they appeared in.” And also they could reconstruct
a human hand image from colon bacteria which have remodeled DNA codes, with 90% accuracy.
The team express that they will
focus on founding molecular recording devices in other cell types and on
engineering the system to memorize biological information, in future work.
July 22, 2017 Junsoo Kwon